Zinc, Metallothionein and Prostate Tumour Cells - Is There Any Relation?

Warning

This publication doesn't include Faculty of Sports Studies. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	GUMULEC Jaromír CERNEI Natalia Vladimirovna ZÍTKA Ondřej MASAŘÍK Michal BABULA Petr ADAM Vojtěch KIZEK René
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Prostate cells are unique in zinc metabolism, because they have the ability to accumulate high levels of these ions. In contrast, prostate cancer cells lack this ability. Metallothioneins (MT) are proteins rich in cysteine. They can bind metals including zinc. Recent studies indicate to elevated serum levels of MTin patients suffering from prostate cancer. Moreover, elevated serum levels of MT are highly specific for prostate cancer and can be potentially used as a new marker of this disease. This could be very desirable because of inaccuracies of current prostatic specific antigen (PSA) screening. The aims of this study is (1) to determine MT levels in patient's serum and cell lines PC-3 and 22RVL and compare to PSA levels, (2) to determine expression of zinc transporters in cell lines and find relations between MT and intracellular zinc levels, (3) to describe potential effects of MT and/or zinc on prostate cancer pathogenesis.
Related projects:	Analýza metalothioneinu u karcinomu prostaty na úrovni DNA, RNA a proteinu Nádorové markery, jejich stanovení a korelace s karcinomem prostaty