Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2

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Authors	WITTE Florian BERNATÍK Ondřej KIRCHNER Katharina MAŠEK Jan MAHL Annika KREJČÍ Pavel MUNDLOS Stefan SCHAMBONY Alexandra BRYJA Vítězslav STRICKER Sigmar
Year of publication	2010
Type	Article in Periodical
Magazine / Source	FASEB JOURNAL
MU Faculty or unit	Faculty of Science
Citation
Doi	http://dx.doi.org/10.1096/fj.09-150615
Field	Genetics and molecular biology
Keywords	Wnt/beta-catenin signaling; casein kinase; Ror2
Description	Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner.
Related projects:	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling Intercellular signalling in development and disease