b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

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Title in English b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?
Authors

SCHULTE Gunnar SCHAMBONY Alexandra BRYJA Vitezslav

Year of publication 2010
Type Article in Periodical
Magazine / Source British Journal of Pharmacology
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Dishevelled; RYK; ROR; b-catenin; canonical signalling; non-canonical signalling; endocytosis; desensitization; internalization; casein kinase
Description Arrestins were originally identified as negative regulators of G protein-coupled receptor signaling. Recently, their diverse functions in intracellular signaling pathways as scaffold and signaling intermediate emerged providing mechanisms for achieving signal specificity and to attack for pharmacological intervention. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signaling. WNTs are secreted lipoglycoproteins acting through the seven transmembrane spanning receptors of the FZD family. During the last years it became evident that beta-arrestins are required for cellular communication by means of WNTs and FZDs both in cellular systems as well as in vivo. Although the overall importance of arrestin for WNT/FZD signaling remains still obscure, interaction with the central phosphoprotein disheveled and the endocytic machinery implicate beta-arrestin as a determinator of WNT signaling specificity, mediator of WNT/FZD desensitization and regulator of signaling compartmentation.
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