On the Role of the cis Hoogsteen:Sugar-Edge Family of Base Pairs in Platforms and Triplets: Quantum Chemical Insights into RNA Structural Biology

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Authors	SHARMA Purshotam SPONER Judit ŠPONER Jiří SHARMA Sitansh BHATTACHARYYA Dhananjay MITRA Abhijit
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Jouranl of Physical Chemistry B
MU Faculty or unit	Faculty of Science
Citation
Field	Physical chemistry and theoretical chemistry
Keywords	quantum chemistry; base pairs; cis Hoogsteen/Sugar edge
Description	Base pairs belonging to the cis Hoogsteen/sugar-edge (H:S) family play important structural roles in folded RNA molecules. We report results of analysis of 30 representative examples spanning 16 possible base pair combinations. The study, involving alternative classification of base pairs and triplets, provides insights into intrinsic properties of these base pairs and their possible structural and functional roles.
Related projects:	Proteins in metabolism and interaction of organisms with the environment