Cyclic nitrones linked to polycyclic aromatic hydrocarbons as a novel approach to DNA intercalators: synthesis and docking studies

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Authors

BUCHLOVIČ Marian KŘÍŽ Zdeněk POTÁČEK Milan

Year of publication 2010
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description We present a synthesis of new derivatives of PAHs that are coupled together with functionalized five-membered cyclic nitrones via a C=C spacer. Synthetic protocol is based on our experience in the allenyloxime chemistry. We examined the effect on calculated DNA intercalation parameters that reflected the interaction of the functionalized nitrone moiety with DNA backbone.
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