Leukaemia Inhibitory Factor Inhibits Cardiomyogenesis of Mouse Embryonic Stem Cells via STAT3 Activation

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Authors

VESELÁ Iva KOTASOVÁ Hana JANKOVSKÁ Štěpánka PROCHÁZKOVÁ Jiřina PACHERNÍK Jiří

Year of publication 2010
Type Article in Periodical
Magazine / Source Folia biologica
MU Faculty or unit

Faculty of Science

Citation
Field Physiology
Keywords LIF; Cardiomyocytes; embryonic stem cells; STAT3
Description LIF is a cytokine that exhibits pleiotropic activities in a wide range of cell types. there are evidences that LIF-regulated signaling pathway are involved in cardiomyogenesis. We studied the effect of LIF on cardiomyogenesis in presence of serum-born factors. We found out that LIF had an inhibitory effect during the induction and progression phases of cardiomyogenesis of mES cells. This effect was abolished by inhibitors of STAT3 activity.
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