Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Nephrology Dialysis Transplantation |
| MU Faculty or unit | |
| Citation | |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | diabetic nephropathy; pentose phosphate pathway; thiamine; thiamine deficiency; transaldolase; transketolase |
| Description | Results of this study indicate dysfunction/deficit of intracellular active form of thiamine in diabetics which serves as a cofactor for transketolase - the key enzyme of pentose phosphate pathway which is considered one of the few potentially counterbalancing pathways opposing hyperglycemia effects. Ascertained functional thiamine deficiency in diabetes, especially when accompanied with advanced renal disease, could be potentially a critical abnormality influencing the activity of pentose phosphate pathway, development if hyperglycemia-mediated damage and diabetic complications and also target of event. pharmacologic interventions. |
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