Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy

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Authors

PÁCAL Lukáš TOMANDL Josef SVOJANOVSKÝ Jan KRUSOVÁ Darja ŠTĚPÁNKOVÁ Soňa ŘEHOŘOVÁ Jitka OLŠOVSKÝ Jindřich BĚLOBRÁDKOVÁ Jana TANHÄUSEROVÁ Veronika TOMANDLOVÁ Marie MUŽÍK Jan KAŇKOVÁ Kateřina

Year of publication 2010
Type Article in Periodical
Magazine / Source Nephrology Dialysis Transplantation
MU Faculty or unit

Faculty of Medicine

Citation
Field Endocrinology, diabetology, metabolism, nutrition
Keywords diabetic nephropathy; pentose phosphate pathway; thiamine; thiamine deficiency; transaldolase; transketolase
Description Results of this study indicate dysfunction/deficit of intracellular active form of thiamine in diabetics which serves as a cofactor for transketolase - the key enzyme of pentose phosphate pathway which is considered one of the few potentially counterbalancing pathways opposing hyperglycemia effects. Ascertained functional thiamine deficiency in diabetes, especially when accompanied with advanced renal disease, could be potentially a critical abnormality influencing the activity of pentose phosphate pathway, development if hyperglycemia-mediated damage and diabetic complications and also target of event. pharmacologic interventions.
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