Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy

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Authors

SLABÝ Ondřej JANČOVIČOVA Jana LAKOMÝ Radek SVOBODA Marek POPRACH Alexandr FABIAN Pavel KŘEN Leoš MICHÁLEK Jaroslav VYZULA Rostislav

Year of publication 2010
Type Article in Periodical
Magazine / Source Journal of experimental & clinical cancer research
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.jeccr.com/content/pdf/1756-9966-29-90.pdf
Doi http://dx.doi.org/10.1186/1756-9966-29-90
Field Oncology and hematology
Keywords MicroRNA; renal cell carcinoma; miRNA-106b; nephrectomy
Description MicroRNAs are endogenously expressed regulatory noncoding RNAs. We examined the expression levels of selected microRNAs in 38 samples of conventional renal cell carcinoma (RCC) and 10 samples of non-tumoral renal parenchyma using TaqMan real-time PCR method. We have confirmed previous observations obtained by miRNA microarray analysis using standardized real-time PCR method. For the first time, we have identified a prognostic significance of miRNA-106b, which, after validation on a larger group of patients, maybe useful as a promising biomarker in patients with RCC.

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