Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy

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Authors	SLABÝ Ondřej JANČOVIČOVA Jana LAKOMÝ Radek SVOBODA Marek POPRACH Alexandr FABIAN Pavel KŘEN Leoš MICHÁLEK Jaroslav VYZULA Rostislav
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Journal of experimental & clinical cancer research
MU Faculty or unit	Faculty of Medicine
Citation
Web	http://www.jeccr.com/content/pdf/1756-9966-29-90.pdf
Doi	http://dx.doi.org/10.1186/1756-9966-29-90
Field	Oncology and hematology
Keywords	MicroRNA; renal cell carcinoma; miRNA-106b; nephrectomy
Description	MicroRNAs are endogenously expressed regulatory noncoding RNAs. We examined the expression levels of selected microRNAs in 38 samples of conventional renal cell carcinoma (RCC) and 10 samples of non-tumoral renal parenchyma using TaqMan real-time PCR method. We have confirmed previous observations obtained by miRNA microarray analysis using standardized real-time PCR method. For the first time, we have identified a prognostic significance of miRNA-106b, which, after validation on a larger group of patients, maybe useful as a promising biomarker in patients with RCC.