Manufacturing of bone marrow-derived mesenchymal stromal cells according to GMP requirements for clinical trials

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Authors	FOLTÁNKOVÁ Veronika KOLÁČNÁ Kateřina MATĚJKOVÁ Eva SMEJKALOVÁ Jana MICHÁLEK Jaroslav
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	MSCs are resident in the bone marrow in small numbers of nucleated cells (0.001-0.01%), but can be readily expanded in vitro to provide sufficient number of GMP grade cells for local and systemic cellular therapy. The methods used in the manufacturing protocol will be validated and the clinical protocol will be approved by Czech State Institute for Drug Control.
Related projects:	Bezpečná biotechnologie alotransplatovaných hematopoetických kmenových buněk u vybraných solidních a hematologických nádorů jako adoptivní imunoterapie