Stem cell marker nestin is expressed in plasma cells of patients with monoclonal gammopathies

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Authors

ŠVÁCHOVÁ Hana POUR Luděk KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana MUTHU RAJA Karthick Raja HÁJEK Roman

Year of publication 2010
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Our results clearly confirmed nestin expression in PCs of MG patients. The percentage of nestin-positive PC and the median fluorescence intensity of expression ranged between patients. Prognostic/predictive significance of these differences requires an evaluation on a larger number of patients and correlation to clinical data. Based on current reports, we hypothesise that nestin could be a prospective marker of myeloma stem cells and a possible target of anti-cancer therapy. Further studies are required to confirm our hypothesis.
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