Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: An expression profiling study.

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Authors	CHLAPEK Petr RÉDOVÁ Martina ZITTERBART Karel HERMANOVÁ Markéta ŠTĚRBA Jaroslav VESELSKÁ Renata
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Journal of Experimental and Clinical Cancer Research
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	neuroblastoma; expression profiling; retinoids; ATRA; caffeic acid; celecoxib
Description	Expression profiling of 440 cancer-related genes in two neuroblastoma cell lines, SK-N-BE(2) a SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and LOX/COX inhibitors was performed. Cluster analyses of the changes in gene expression showed the concentration-dependent increase in genes known to be involved in the process of retinoid-induced neuronal differentiation, especially in cytoskeleton remodeling. These changes were detected in both cell lines, and they were independent of the type of specific inhibitors, suggesting a common mechanism of ATRA-induced differentiation enhancement.
Related projects:	Modulace antineoplastického efektu retinoidů LOX/COX inhibitory na modelu dětských solidních nádorů: in vitro studie