Persistent splenomegaly during imatinib therapy and the definition of complete hematological response in chronic myelogenous leukemia.

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Authors	RÁČIL Zdeněk KLAMOVÁ Hana VOGLOVÁ Jaroslava FABER Edgar RÁZGA Filip ŽÁČKOVÁ Daniela BUREŠOVÁ Lucie CETKOVSKÝ Petr MAYER Jiří
Year of publication	2010
Type	Article in Periodical
Magazine / Source	American Journal of Hematology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	persistent splenomegaly; CML; CHR
Description	Splenomegaly belongs among typical findings on physical examination in patients with newly diagnosed chronic myelogenous leukemia (CML). Its disappearance is a part of achieving complete hematological response (CHR), that is nowadays (when second generation of tyrosine kinase inhibitors are available) of particular interest during imatinib treatment.
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