Role genetické variability genu pro fruktosamin-3-kinázu v progresi diabetické nefropatie a mortalitě diabetiků

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Title in English	Role of genetic variability in the gene for fructosamine-3-kinase in the progression of diabetic nephropathy and mortality of diabetics
Authors	TANHÄUSEROVÁ Veronika SVOJANOVSKÝ Jan KRUSOVÁ Darja ŠTĚPÁNKOVÁ Soňa OLŠOVSKÝ Jindřich BĚLOBRÁDKOVÁ Jana ŘEHOŘOVÁ Jitka SMRŽOVÁ Jana HERTLOVÁ Miluše MUŽÍK Jan PÁCAL Lukáš KAŇKOVÁ Kateřina
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Fructosamines are products of non-enzymatic glycation formed in accelerated rate during hyperglycemia. As precursors of advanced glycation end-products (AGEs) fructosamines supposedly contribute to the development of glucotoxic injury. Mechanism of enzymatic deglycation of proteins in vivo by fructosamine-3-kinase (FN3K) was described recently. The -385A/G (rs3859206) and 900C/G (rs1056534) single nucleotide polymorphisms (SNPs) in the FN3K gene were found to have potential functional impact.The aim was to study relationship between polymorphisms in FN3K gene, progression of diabetic nephropathy (DN) and cardiovascular morbidity and mortality of diabetics. Based on our results, we can identify genetic variability in the FN3K gene as a factor influencing progression of DN and cardiovascular mortality of diabetics.
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