Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

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Authors	ŠMEJKAL Karel ŠLAPETOVÁ Tereza KRMENČÍK Pavel KUBÍNOVÁ Renata SUCHÝ Pavel DALLACQUA Stefano INNOCENTI Gabbriella VANČO Ján KALVAROVÁ Karolína DVORSKÁ Margita SLANINA Jiří KRAMÁŘOVÁ Eva MUSELÍK Jan ŽEMLIČKA Milan
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Molecules
MU Faculty or unit	Faculty of Medicine
Citation
Field	Organic chemistry
Keywords	Schisandra chinensis; dibenzocyclooctadiene lignans; antiradical; diabetes mellitus
Description	The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxaninduced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.
Related projects:	Regulace biosyntézy sekundárních metabolitů v buněčné kultuře Schisandra chinensis