Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Developmental dynamics |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Wnt5a; Lrp6; somitogenesis; development |
| Description | Lrp6 is generally described as a receptor required for signal transduction in the Wnt/b-catenin pathway. Wnt5a, however, is a Wnt ligand which usually does not activate Wnt/b-catenin but rather activates non-canonical Wnt signaling. Here we describe phenotypes found in Wnt5a/Lrp6 compound mutant mice, including a worsening of individual Wnt5a or Lrp6 loss of function phenotypes. Lrp6 haploinsufficiency in a Wnt5a-/- background caused spina bifida and exacerbated posterior truncation. |
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