Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development

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Authors

ANDERSSON Emma BRYJOVÁ Lenka BIRIS Kristin YAMAGUCHI Terry ARENAS Ernest BRYJA Vítězslav

Year of publication 2010
Type Article in Periodical
Magazine / Source Developmental dynamics
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Wnt5a; Lrp6; somitogenesis; development
Description Lrp6 is generally described as a receptor required for signal transduction in the Wnt/b-catenin pathway. Wnt5a, however, is a Wnt ligand which usually does not activate Wnt/b-catenin but rather activates non-canonical Wnt signaling. Here we describe phenotypes found in Wnt5a/Lrp6 compound mutant mice, including a worsening of individual Wnt5a or Lrp6 loss of function phenotypes. Lrp6 haploinsufficiency in a Wnt5a-/- background caused spina bifida and exacerbated posterior truncation.
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