One-pot, three-component synthesis of five-membered cyclic nitrones by addition/cyclization/condensation domino reaction

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Authors	BUCHLOVIČ Marian MAN Stanislav KISLITSON Konstantin MATHOT Charlotte POTÁČEK Milan
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Tetrahedron
MU Faculty or unit	Faculty of Science
Citation	BUCHLOVIČ, Marian, Stanislav MAN, Konstantin KISLITSON, Charlotte MATHOT and Milan POTÁČEK. One-pot, three-component synthesis of five-membered cyclic nitrones by addition/cyclization/condensation domino reaction. Tetrahedron. Oxford (UK): Elsevier Science Ltd., 2010, vol. 2010, No 66, p. 1821-1826. ISSN 0040-4020.
Field	Organic chemistry
Keywords	Allenes;allenyloxime;cyclic nitrones;heterocyclizations;one-pot;domino reactions
Description	A new approach to five-membered cyclic nitrones connected with the incorporation of a planar aromatic ring system into the structure is described. This procedure is based on an allenyloxime one-pot domino transformation under simple base catalysis in alcoholic and aqueous solvents. The structure of obtained nitrones was studied by X-ray analysis and the reactivity of products in 1,3-dipolar cycloadditions was tested.
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