Computational Study of MutH Recognition and Catalysis

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Authors	KULHÁNEK Petr MONES Letif SIMON Istvan FUXREITER Monika
Year of publication	2009
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	MutH enzyme participates in methyl-directed DNA repair together with two other enzymes MutS and MutL. Their joint choreography is conceptually known but a lot of details are still elusive. We aim to resolve to two challenging questions related to the recognition and catalytic activity of MutH by utilizing computational techniques. 1) How a single methyl group attached to a far-lying adenine base from the active site can determine the activity of MutH? 2) Is Lys-77 residue serves to couple recognition to catalysis?
Related projects:	Program developing interdisciplinary research POtential for the STudies of BIOMolecular INteractions