Sensing of human plasma fibrinogen on polished, chemically etched and carbon treated titanium surfaces by diffractive optical element based sensor.

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Authors	SILVENNOINEN Raimo VETTERL Vladimír HASOŇ Stanislav TUONONEN Hejkli SILVENNOINEN Martti MYLLER Kari CVRČEK Ladislav VANĚK Jiří PRACHÁR Patrik
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Optics Express
MU Faculty or unit	Faculty of Medicine
Citation
Field	Biophysics
Keywords	PROTEIN ADSORPTION; PHASE TRANSIENTS; IMPLANT SURFACES; IN-VITRO; OXIDE; DIAGNOSTICS; ACTIVATION; ROUGHNESS; ADENOSINE; CERAMICS
Description	Adsorption of human plasma fibrinogen (HPF) on 6 differently treated titanium samples (polished, polished and etched, and 4 titanium carbide coatings samples produced by using plasma-enhanced chemical vapour deposition (PECVD) method) is investigated by using diffractive optical element (DOE) sensor. Permittivity (susceptibility) change and fluctuation in optical roughness (R-opt) of treated titanium surface in the presence of background electrolyte without and with HPF molecules are sensed by using DOE sensor and optical ellipsometry. Correlation between transmitted light and thickness of molecule layer was found. The findings allow to sense temporal organization and severity of adsorption of nano-scale HPF molecules on polished, on polished and etched, and on titanium carbide surface.
Related projects:	Dental research centre Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine