Thermodynamic and kinetic studies of lanthanide(III) complexes with mono(pyridine-N-oxide) analog of DOTA

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Authors

HERMANN Petr LUBAL Přemysl VANĚK Jakub POLÁŠEK Miloš

Year of publication 2009
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Ln(III) complexes of H4dota and its derivatives are utilized in many areas of medicine (e.g. complexes of metal radioisotopes as 90Y, 153Sm, 166Ho, 177Lu in nuclear medicine, Gd(III) complexes as MRI contrast agents, Eu(III) or Tb(III) complexes as luminescent probes). In this contribution, the thermodynamic and kinetic properties of Y(III) and Ln(III) complexes (Ln = Ce, Eu, Gd, Yb) of the mono(pyridine-N-oxide) H4dota derivative were studied by molecular absorption and emission spectroscopies (in UV/VIS region, luminescence, TRFS). The mechanisms of complex formation (pH = 5.0-6.0, t = 25 degrees of Celsius, I = 0.1 M KCl) and acid-assisted complex dissociation (t = 25-70 degrees of Celsius, I = 3.0 M (Na,H)ClO4) were proposed. Achieved results can be used for fluorimetric determination of Ln(III) ions in mixture.
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