Expression pattern of HLA class I antigens in renal cell carsinoma and primary cell line cultures: Methodological implications for immunotherapy

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Authors

HANÁK Libor SLABÝ Ondřej LAUEROVÁ Ludmila KŘEN Leoš NENUTIL Rudolf MICHÁLEK Jaroslav

Year of publication 2009
Type Article in Periodical
Magazine / Source Medical Science Monitor (International Medical Journal of Experimental and Clinical Research)
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords renal carcinoma; immunotherapy; HLA antigens
Description In this study both classic and non-classic HLA cals I antigens were tested in tumor specimens and estabilished primary cell cultures derived from renal cell carcinoma patients. Our findings suggest that primary cell line cultures derived from surgical specimens of renal cell carcinomas are a feasible model for immunotherapy research through their high cultivation protential.
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