Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Proceedings |
| Conference | Journal of Investigative Dermatology |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | T cell lymphoma; endocannabinoids; SNP; association study |
| Description | Endocannabinoids are lipid mediators thought to modulate central and peripheral neural functions. Recently, the overexpressionof the central and peripheral cannabinoid receptors CB1 and CB2 was reported in various types of lymphomas. Therefore, the aim of the study was to investigate possible associations of 3 common SNPs in CNR1 gene (rs1049343, rs12720071 and rs806368) with cutaneous T-cell lymphoma. The total of 97 patients with CTCL were recruited for the study along with 258 healthy Czech individuals of similar age and gender distribution. No significant differences in genotype distributions as well as allele frequencies were observed between the CTCL cases and controls. Five common haplotypes in the CNR1 gene were identified, whereas the frequencies of the haplotypes differed significantly betweent the cases and the controls (Phap less than 0.001). In the multivariate modelling, the CNR1 4895 C/T (rs806368) expressed an independent prediction role for the CTCL staging (beta = -0.27, P = 0.05). Based on our results, the CNR1 gene could be considered a susceptibility marker for cutaneous T-cell lymphoma. |