Trans Hoogsteen/Sugar Edge Base Pairing in RNA. Structures, Energies, and Stabilities from Quantum Chemical Calculations

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Authors	MLÁDEK Arnošt SHARMA Purshotam MITRA Abhijit BHATTACHARYYA Dhananjay ŠPONER Jiří ŠPONER Judit
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Journal of Physical Chemistry B
MU Faculty or unit	Faculty of Science
Citation
Field	Biophysics
Keywords	quantum chemistry; base pairing; RNA
Description	Trans Hoogsteen/sugar edge (H/SE) RNA base pairs form one of the six families of RNA base pairs that utilize the 2hydroxyl group of ribose for base pairing and play key roles in stabilizing folded RNA molecules Here, we provide a detailed quantum chemical characterization of intrinsic structures and interaction energies of this base pair family, along with the evaluation of solvent screening effects by a continuum solvent approach.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Biomolecular centre