Effect of ID ACE gene polymorphism on dietary composition and obesity-related anthropometric parameters in the Czech 4 adult population

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Authors	BIENERTOVÁ VAŠKŮ Julie BIENERT Petr SÁBLÍKOVÁ Lenka SLOVÁČKOVÁ Lenka FOREJT Martin PISKÁČKOVÁ Zlata KUČEROVÁ Lenka HECZKOVÁ Kateřina DERFLEROVÁ BRÁZDOVÁ Zuzana VAŠKŮ Anna
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Genes and Nutrition
MU Faculty or unit	Faculty of Medicine
Citation
Field	Genetics and molecular biology
Keywords	ID ACE; obesity; polymorphism; food intake
Description	Background: The aim of this study was to investigate the possible associations of insertion/deletion (ID) polymorphism in angiotensin-converting enzyme (ACE) (dbSNP rs 4646994) with the food intake and body composition in the Czech non-obese, obese and extremely obese populations. Material and methods: The total of 453 various-weighted individuals were enrolled in the study and were according to their BMI assigned into following subgroups: obese (BMI between 30 and 40), morbidly obese (BMI more than 40) and non-obese (20260g of carbohydrates/d, respectively. Conclusion: Based on our findings, the ID ACE polymorphism could represent a gene modulator of carbohydrate intake in morbidly obese Czech population; the strong significant effect of DD genotype was observed in the phenotypes of extreme obesity with the highest carbohydrate intake.