Construction of mutant lectins from Chromobacterium violaceum and study of changes in their binding properties

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Authors

BRŮNOVÁ Lenka DEJMKOVÁ Eva WIMMEROVÁ Michaela

Year of publication 2009
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description The aim of this work is in vitro creation of mutant lectins from oportunistic human pathogen Chromobacterium vioalceum. Substitution of amino acids in the lectin structure should lead to changes of lectin sugar specificity. Mutation were focused on the "specificity binding loop" in the position 22-23-24 and in other position 97. The work is going to be followed by structural and functional analysis.
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