Construction of mutant lectins from Chromobacterium violaceum and study of changes in their binding properties

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Authors	BRŮNOVÁ Lenka DEJMKOVÁ Eva WIMMEROVÁ Michaela
Year of publication	2009
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	The aim of this work is in vitro creation of mutant lectins from oportunistic human pathogen Chromobacterium vioalceum. Substitution of amino acids in the lectin structure should lead to changes of lectin sugar specificity. Mutation were focused on the "specificity binding loop" in the position 22-23-24 and in other position 97. The work is going to be followed by structural and functional analysis.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Biomolecular centre