Fluorescence properties of selected benzo[c]phenantridine and studies of their interaction with CT DNA

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Authors

URBANOVÁ Jana LUBAL Přemysl SLANINOVÁ Iva TÁBORSKÁ Eva TÁBORSKÝ Petr

Year of publication 2009
Type Article in Periodical
Magazine / Source Analytical and Bioanalytical Chemistry
MU Faculty or unit

Faculty of Science

Citation
Web http://www.springerlink.com/content/w074311u085u584j/fulltext.pdf
Field Biochemistry
Keywords Sanguinarine Chelirubine Sanguirubine Chelilutine Macarpine
Description The spectral, especially fluorescence properties, of seven selected quaternary benzo[c]phenantridine alkaloids (sanguinarine, chelerythrine, chelirubine, sanguirubine, chelilutine, sanguilutine, and macarpine) were studied in presence and in absence of double-stranded DNA. This study has proved dramatic differences in fluorescence emission of all studied alkaloids in presence of calf thymus DNA in comparison to fluorescence of free alkaloids. The most remarkable are changes in emission spectra of macarpine, chelirubine, and sanguirubine. Association constants (logK) for interaction of all studied alkaloids with CT DNA were calculated.
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