Markers of oxidative stress in patients with acute heart failure following acute myocardial infarction

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Authors	TOMANDL Josef PAŘENICA Jiří KALA Petr POLOCZEK Martin NEUGEBAUER Petr TOMAN Ondřej PRYMUSOVÁ Krystyna KUBKOVÁ Lenka TÁBORSKÁ Eva ŠPINAR Jindřich
Year of publication	2009
Type	Article in Proceedings
Conference	Cor et Vasa - Supplementum
MU Faculty or unit	Faculty of Medicine
Citation
Field	Biochemistry
Keywords	oxidative stress; acute myocardial infarction; acute heart failure; malondialdehyde
Description	Oxidative stress and persistent inflammation are implicated in the progression of heart failure. The aim of the study was to investigate selected parameters of oxidative stress (malondialdehyde, vitamins A and E and tumor necrosis factor alpha) in patients with acute heart failure after acute myocardial infarction. Plasma values of vitamins were almost within reference interval. Levels of malondialdehyde and TNF alpha were elevated in 18 and 46 % patients on admission, respectively. Level of malondialdehyde correlated positively with TNF alpha and vitamin A and level of TNFalpha correlated negatively with vitamin E on admission. In contrast to these correlations, there were no significant relationships between measured parameters and LV ejection fraction.
Related projects:	Early diagnostics and treatment of cardiovascular diseases