Disruption of retinoid transport, metabolism and signaling by environmental pollutants

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Authors

NOVÁK Jiří BENÍŠEK Martin HILSCHEROVÁ Klára

Year of publication 2008
Type Article in Periodical
Magazine / Source Environment International
MU Faculty or unit

Faculty of Science

Citation
Field Environment influence on health
Keywords vitamin A; all-trans retinoic acid; pesticide; TCDD; polychlorinated biphenyls; retinoids
Description Disruption of retinoid transport, metabolism and signaling by environmental pollutants. - a review. Although the assessment of circulatory levels of retinoids has become a widely used biomarker of exposure to environmental pollutants, the adverse effects caused by imbalance of the retinoid metabolism and signaling in wildlife are not known in detail. Retinoids play an important role in controlling such vital processes as morphogenesis, development, reproduction or apoptosis. Unlike other signaling molecules, retinoids are not strictly endogenous but they are derived from dietary sources of vitamin A or its precursors and thus they are sometimes referred to as dietary hormones. Some environmental pollutants that affect embryogenesis, immunity or epithelial functions were also shown to interfere with retinoid metabolism and signaling in animals. This suggests that at least some of their toxic effects may be associated with interaction with the retinoid metabolism, transport or signal transduction. This review summarizes in vivo and in vitro studies on interaction of environmental complex samples, pesticides, polychlorinated dioxins, polychlorinated biphenyls, polycyclic aromatic compounds and other organic pollutants with metabolism and signaling of retinoids. It sums up contemporary knowledge about levels of interaction and mechanisms of action of the environmental contaminants.
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