The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.

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Authors

BRYJA Vítězslav ANDERSSON Emma R. SCHAMBONY Alexandra ESNER Milan BRYJOVÁ Lenka BIRIS Kristin K. HALL Anita C. KRAFT Bianca ČAJÁNEK Lukáš YAMAGUCHI Terry P. BUCKINGHAM Margaret ARENAS Ernest

Year of publication 2008
Type Article in Periodical
Magazine / Source : Molecular Biology of the Cell
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords non-canonical Wnt signalling; Lrp5/6; mouse; Xenopus
Description Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and Xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo.
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