Význam sledování exprese nádorových testikulárních antigenů u mnohočetného myelomu a monoklonálních gamapatií

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Title in English Impact of cancer/testis antigens /(CTA) expression in multiple myeloma (MM) and monoclonal gammapathy (MGUS)
Authors

NEČASOVÁ Jana KADLECOVÁ Jitka KADLECOVÁ Jitka SPĚŠNÁ Renata SPĚŠNÁ Renata PENKA Miroslav PENKA Miroslav HÁJEK Roman HÁJEK Roman

Year of publication 2008
Type Article in Periodical
Magazine / Source Klinická onkologie Supplement 2008
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords multiple myeloma; monoclonal gammapathy; cancer/testis antigen
Description The human MAGE gene family which is a group of "cancer/testis antigens" (CTA) encodes products that can be recognized by autologous cytotoxic T cells. CT antigens are expressed in several malignant tumors, but not in normal tissues except for testis and placenta. CT antigens are frequently expressed in MM and represents promising candidates for cancer- specific immunotherapy in multiple myeloma. An obvious correlation between the expression of these genes and the stage of the disease has been observed. We examined the expression of MAGE-A1 and MAGE-A3 in bone marrow in a group of patiens with monoclonal gammapathy and in patients with early and advanced stage of the multiple myeloma.
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