Wrestling SUMO on proteins involved in homologous recombination

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Authors	ALTMANNOVÁ Veronika KREJČÍ Lumír
Year of publication	2008
Type	R&D Presentation
MU Faculty or unit	Faculty of Science
Citation
Description	Homologous recombination (HR) is a process widespread in nature and essential to maintain the integrity of the genome via repair of DNA double-strand breaks (DSBs). Rad52 is a DNA-binding protein which plays a key role in HR. It mediates the exchange of the recombination factor RPA associated to single-stranded DNA (ssDNA) by Rad51, resulting in the assembly of the presynaptic filament. Recently, it has been reported that upon DNA damage Rad52 is modified by the small ubiquitin-like modifier (SUMO) protein which shelters Rad52 against proteosomal degradation. As the major SUMOylation sites of Rad52, three lysines (K43, K44, K253) have been identified. The effect of Rad52 DNA binding and interaction with its partners was tested to clarify the regulatory mechanism of Rad52 SUMOylation.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Srs2 protein and its multi-functional role in rekombination/repair processes