Studies of selected oligonucleotides reactivity with Os,bipy

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Authors	BITTOVÁ Miroslava KOSTEČKA Pavel TRNKOVÁ Libuše FOJTA Miroslav
Year of publication	2008
Type	Article in Proceedings
Conference	Electrochemistry of Nucleic Acids and Proteins. Book of Abstracts
MU Faculty or unit	Faculty of Science
Citation
Field	Electrochemistry
Keywords	oligonucleotide; Os.bipy
Description	In this work, the reactivity of Os,bipy with various pentanucleotides was studied by capillary zone electrophoresis and square-wave voltammetry. Our experiments examined influence of different ON:Os,bipy ratio and temperature of modification on complex formation. In agreement with previously reported results, the most reactive pyrimidine is thymine; reactivity decreases in line thymine, methylcytosine, uracil and cytosine.
Related projects:	Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine