Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population

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Authors	BIENERTOVÁ VAŠKŮ Julie ŠPINAROVÁ Lenka BIENERT Petr VAŠKŮ Anna
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Heart Vessels
MU Faculty or unit	Faculty of Medicine
Citation
Field	Genetics and molecular biology
Keywords	Adipokines ; Polymorphisms; Leptin; Leptin receptor; Proopiomelanocortin; Chronic heart failure
Description	Patients with chronic heart failure (CHF) express enhanced catabolic metabolism finally resulting in overall weight loss, whereas adipokines might play a crucial role in signaling among tissues. The role of the polymorphic variants in the genes encoding for adipokines as potential CHF susceptibility genes is unclear. Based on our findings, the LEPR Gln223Arg polymorphism could be considered a disease susceptibility modulating factor both in ischemic heart disease or dilated cardiomyopathy patients.