Repeated exposure to methamphetamine and methanandamide changes relative expression of D1 receptor in mouse midbrain

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Authors	LANDA Leoš JURAJDA Michal
Year of publication	2008
Type	Article in Periodical
Magazine / Source	European Neuropsychopharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	PCR; behavioural sensitization; methamphetamine; cannabinoids; D1 receptor; mesencephalon
Description	The results of the behavioural investigation showed: a) significant stimulatory influence of methamphetamine after the acute administration, b) development of sensitization to methamphetamine after its repeated treatment, c) development of cross-sensitization to methamphetamine after repeated pre-treatment with CB1 receptor agonist methanandamide. Real-time PCR results showed increased D1 mRNA expression both in animals sensitized to methamphetamine and in animals cross-sensitized to methamphetamine (repeatedly pre-treated with methanandamide).
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.