Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer

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Authors	SVOBODA Miroslav IZAKOVIČOVÁ HOLLÁ Lydie ŠEFR Roman VRTKOVÁ Irena KOCÁKOVÁ Ilona TICHÝ Boris DVOŘÁK Josef
Year of publication	2008
Type	Article in Periodical
Magazine / Source	International Journal of Oncology
MU Faculty or unit	Faculty of Medicine
Citation	SVOBODA, Miroslav, Lydie IZAKOVIČOVÁ HOLLÁ, Roman ŠEFR, Irena VRTKOVÁ, Ilona KOCÁKOVÁ, Boris TICHÝ and Josef DVOŘÁK. Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer. International Journal of Oncology. Athens, Greece: International Center for Cancer Research, 2008, vol. 33, No 3, p. 541-547. ISSN 1019-6439.
Field	Oncology and hematology
Keywords	micro-RNA; miR125b; miR137; preoperative chemoradiotherapy; rectal cancer
Description	The aim of this study was to test the possible involvement of micro-RNAs in response to standard anticancer treatment. Our results for the first time show that higher induced levels of miR125b and miR137 are associated with worse response to the therapy.
Related projects:	Genetické determinanty pro-/antioxidační rovnováhy v patogeneze respiračních nemocí