Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus

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Authors	ŠLAIS Karel VOŘÍŠEK Ivan ZOREMBA Norbert HOMOLA Aleš DMYTRENKO Lesia SYKOVÁ Eva
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Experimental Neurology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	Diffusion; ADCW; Microdialysis; Pilocarpine; Epilepsy; Glucose; Glutamate; Pyruvate; Lactate; Potassium
Description	The real-time iontophoretic method using tetramethylammonium-selective microelectrodes and diffusion-weighted magnetic resonance imaging were used to measure the extracellular space volume fraction, tortuosity and apparent diffusion coefficient of water (ADCW) 240 min after the administration of pilocarpine in urethane-anaesthetized rats. The obtained data were correlated with extracellular lactate, glucose, and glutamate concentrations and the lactate/pyruvate-ratio, determined by intracerebral microdialysis.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.