Cholecystektomie - rizikový faktor karcinomu endometria?
| Title in English | Cholecystectomy - a risk factor for the endometrial cancer? |
|---|---|
| Authors | |
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Česká gynekologie |
| MU Faculty or unit | |
| Citation | |
| Field | Gynaecology and obstetrics |
| Keywords | endometrial carcinoma; cholelithiasis; cholecystectomy; obesity; hormonal factors |
| Description | The aim of the study was to find out if the incidence of cholecystectomy is more frequent in patients with endometrial carcinoma and if the incidence of the anamnestic information concerning cholecystectomy in patients with endometrial carcinoma influences the course and the result of the treatment of the tumorous disease. 470 females with endometrial carcinoma were entered into the study, the group was divided into the patients who have had cholecystectomy and those who had not had it. There was a control group of 370 females. All participants were diagnosed and subsequently treated at the Department of Gynecology and Obstetrics of Masaryk University affiliated Hospital, Brno, between January 2004 and December 2006. We have not proved any statistically significant difference concerning the origin of the endometrial carcinoma after a performed cholecystectomy. There was no difference in grading as well as the stage according to the FIGO standards. Nonetheless, we can say that the patients with the endometrial cancer and cholecystectomy have significantly higher BMI. The relation between cholecystectomy and the endometrial carcinoma can be influenced by various factors. However, we can assume that the pathological processes of cholelithiasis are pathophysiologically connected with the development of changes, which fall within the category of hormonal risk factors for the development of endometrial carcinoma. |