Studium obsahu metalothioneinu v krevnim seru pacientu se zmenenou hladinou medi nebo cisplatiny pomoci automatizovane elektrochemicke detekce
| Title in English | Study of metallothionein level in patients serum with changed copper or cisplatinum level by automatic electrochemic detection |
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| Authors | |
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | Toxcon 2007; 12. Interdisciplinary Slovak - Czech Toxicological Conference |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | Metallothionein; Brdicka reaction |
| Description | Metallothionein is distinguished detoxicated protein of human organism. Our suggested method of metallothionein detection is Based on Brdicka reaction. Due to interaction of metallothionein with Co3+ ions in basic electrolyte occur on mercury electrod an catalytic signals of hydrogen exudation from basic electrolyte. The samples were analyzed by means of differential pulse voltammetry - Brdicka reaction. The aim of this study was to optimize metallothionein determination by automatic electrochemic analysator and obtained advance aplly for analysis of patients real samples with changed contant of copper and cisplatinum in blood. |
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