Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions

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Authors

NOVÁKOVÁ Marie BRUDEROVÁ Viera SULOVÁ Zdena KOPÁČEK Juraj LACINOVÁ Ľubica KVETŇANSKÝ Richard VAŠKŮ Anna KAPLAN Peter KRIŽANOVÁ Olga JURKOVIČOVÁ Dana

Year of publication 2007
Type Article in Periodical
Magazine / Source General Physiology and Biophysics
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords Sigma receptors;IP3 receptors;Stress;Gene expression
Description The aim of the present work was to study the effect of various stressors (hypoxia, cold, immobilization) on the gene expression of sigma receptors in the left ventricles of rat heart. We have clearly shown that gene expression of sigma receptors is upregulated by strong stress stimuli, such as immobilization and/or hypoxia. Nevertheless, cold as a milder stressor has no effect on sigma receptors mRNA levels. Signalling cascade of sigma receptors is dependent on IP3 receptors, since silencing of both, type 1 and 2 IP3 receptors resulted in decreased mRNA levels of sigma receptors. Physiological relevance of sigma receptors in the heart is not clear yet. Nevertheless, based on the already published data we can assume that sigma receptors might participate in contractile responses in cardiomyocytes.
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