INTERFERENCE OF PAHs AND THEIR DERIVATIVES WITH SIGNALING OF RETINOIDS

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Authors	BENÍŠEK Martin BLÁHA Luděk PACHERNÍK Jiří HILSCHEROVÁ Klára
Year of publication	2006
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	For studying the disruption, we used new in vitro method with the cell line P19/A15. It is murine embryonal P19 cell line stably transfected with luciferase reporter gene under the control of RARE (Retinoic Acid Responsive Element). Xenobiotics potentially interacting with the retinoid signaling can either induce luciferase expression and/or negatively affect retinoic acid (ATRA)-induced luciferase activity. For our study we selected the group of PAH and their N-heterocyclic analogs especially for their widespread environmental occurrence and possible teratogenic effects. We tested 13 N-PAHs and 6 PAHs for retinoid and antiretinoid activity.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants