p53 arrests growth and induces differentiation of v-myb-transformed monoblasts

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Authors	ŠMARDA Jan NAVRÁTILOVÁ Jarmila HORVÁTH Viktor KOZUBÍK Alois LOJEK Antonín
Year of publication	2007
Type	Article in Proceedings
Conference	Molecular Aspects of myeloid stem cell development and leukemia
MU Faculty or unit	Faculty of Science
Citation
Field	Oncology and hematology
Keywords	Myb; p53; differentiation; apoptosis; cell growth
Description	Ectopic expression of human p53 in avian leukemic monoblasts BM2 induces cell cycle arrest in G2, early monocytic differentiation but no apoptosis. This suggests that the species-specific differences of the p53 molelecules,promoter/enhancers, co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilities of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein.
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