Sledování aktivity CYP2D6 u pacientek s mentální bulimií (vliv na jídlení chování a sexuální aktivitu)

• Title in English: Bulimia Nervosa and CYP2D6 Activity (Influence on Eating Behaviour and Sexual Acitivty)
• Authors: PALČÍKOVÁ Ivana; ŽOURKOVÁ Alexandra; VALENTOVÁ Daria
• Year of publication: 2007
• Type: Article in Periodical
• Magazine / Source: Česká a slovenská psychiatrie
• MU Faculty or unit: Faculty of Medicine
• Field: Psychiatry, sexuology
• Keywords: bulimia; paroxetine; CYP2D6
• Description: Genetically conditioned change in activity of SSRI metabolizing enzymes may lead to different therapeutic response of patients, ranging from lack of efficacy to symptoms of toxicity and a significant incidence of drug-drug interactions. The activity of P 450 cytochromes can be determined by genotyping or phenotyping. CYP2D6, cytochrome P-450 isoenzyme, is a catalyzing enzyme of a number of frequently used SSRI and has been known to be genetically polymorphous. The goal of the study was to evaluate the efficacy of paroxetine treatment in female patients with mental bulimia (MB) while monitoring CYP2D6 activity

Related projects

• The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.