Two common polymorphisms in leptin and adiponectin genes are not associated with preeclampsia in the Czech population
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| Year of publication | 2007 |
| Type | Conference abstract |
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| Description | Introduction Leptin and adiponectin are both adipocyte-derived hormones that regulate food intake and have also autocrine-paracrine effects. Leptin has been previously reported to control the integrity of fetoplacental unit by virtue of its immunomodulatory property mediated via T-lymphocytes. Dysregulation of complex interactions of various adipokines is supposed to be implicated in the pathogenesis of recurrent miscarriage, gestational diabetes or preeclampsia. In this study, we investigated whether two common polymorphisms in leptin and adiponectin gene were associated with preeclampsia and its related variables (blood pressure, proteinuria, glucose concentrations, and anthropometric parameters of the newborns). Methods A total of 140 preeclamptic women and 153 healthy controls were genotyped for the T94G in the adiponectin (APM1) gene exon 2 and the G-2548A in the leptin (LEP) gene promoter. Results The allelic frequency of G allele of LEP G-2548A was 0.541 in preeclamptic women vs. 0.583 in age-matched healthy pregnant controls (pa=0.316); the frequency of G allele of APM1 T94G was 0.073 in preeclamptic cases and 0.079 in healthy controls (pa=0.762), respectively. No significant associations were detected between the two SNPs evaluated and the anthropometric variables including BMI, blood pressure, glucose, fibrinogene concentrations and the birth length and weight of the newborns from these pathological vs. physiological pregnancies. Conclusion To conclude, the APM1 T94G and LEP G-2548A polymorphisms do not seem to be major genetic determinants of preeclampsia in Czech Caucasian population. |