Interaction of haloperidol with IKto-channels in cardiac cells: a quantitative model

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Authors

PÁSEK Michal BÉBAROVÁ Markéta MATEJOVIČ Peter NOVÁKOVÁ Marie

Year of publication 2006
Type Article in Proceedings
Conference Human Biomechanics 2006
MU Faculty or unit

Faculty of Medicine

Citation
Field Biophysics
Keywords IKto-channel;haloperidol;quantitative model
Description Haloperidol inhibited the transient outward potassium current IKto with decrease of peak current, acceleration of the time course of apparent inactivation and deceleration of recovery from inactivation and block. The quantitative model predicted interaction of haloperidol with both open and open-inactivated states as the most probable mechanism of IKto-block.
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