Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes

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Authors

BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal ŠIMURDOVÁ Milena ŠIMURDA Jiří

Year of publication 2005
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Ajmaline decreased the upstroke velocity of action potential and its amplitude, very likely by inhibition of sodium current INa. The observed prolongation of action potential was probably related to the inhibition of transient outward potassium current Ito, the main repolarizing current in rat. This effect predominates over the opposite effect of the inhibition of calcium current ICaL, partly because of lower IC50.
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