Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes

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Authors	BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal ŠIMURDOVÁ Milena ŠIMURDA Jiří
Year of publication	2005
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Ajmaline decreased the upstroke velocity of action potential and its amplitude, very likely by inhibition of sodium current INa. The observed prolongation of action potential was probably related to the inhibition of transient outward potassium current Ito, the main repolarizing current in rat. This effect predominates over the opposite effect of the inhibition of calcium current ICaL, partly because of lower IC50.
Related projects:	Early diagnostics and treatment of cardiovascular diseases