p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Differentiation |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | p53; differentiation; cell cycle; apoptosis; monoblast |
| Description | The p53 protein can control cell cycle progression, programmed cell death and differentiation of many cell types. In this work, we expressed human p53 protein in v-Myb-transformed chicken monoblasts. We found that even this protein possessing only 53% amino acid homology to its avian counterpart can significantly alter morphology and physiology of these cells causing the G2-phase cell cycle arrest and early monocytic differentiation. Our results document that the species-specific differences of the p53 molecules, promoters/enhancers, and co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilites of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein. The p53-induced differentiation and cell cycle arrest of v-Myb-transformed monoblasts are not associated with apoptosis suggesting that the p53-driven pathways controling apoptosis and differentiation/proliferation are independent. |
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