Comparison of toxic effects of PAHs and their N-heterocyclic analogues to enchytraeid Enchytraeus crypticus

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Authors	KOBETIČOVÁ Klára HOFMAN Jakub HOLOUBEK Ivan
Year of publication	2006
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	Polycyclic aromatic hydrocarbons and their N-heterocycles (azaPAHs) are ubiquitous environmental pollutants and they are frequently present in contaminated soils. The aim of this study was compared the toxic effects of some two- and three-ringed PAHs (naphthalene, phenanthrene, anthracene) and their N-heterocyclic analogues with one (quinoline, acridine, phenanthridine) or two (quinoxaline, phenazine, 1,10-phenanthroline) nitrogen atoms on Enchytraeus crypticus survival and reproduction in OECD artificial soil test. The results did not indicate clear relationships between the toxicity and chemical structure of compounds. However, some trends were apparent and a kind of "pseudo-QSAR" might be possible. The final toxic effect in soil was affected both by individual compound fate in soil (bioavailability) and by specific mode of action to E.crypticus. Both these components must be included in the QSAR calculation in the soil. This research was supported by Grant Agency of Czech Republic 525/04/P159
Related projects:	Effects of newly recognized priority persistent organic pollutants (POPs) on organisms of soil ecosystem Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)