Riziková medikace a kontrastní látkou indukovaná nefropatie u pacientů s diabetem a hypertenzí
| Title in English | Risky medication and contrast media-induced nephropathy in patients with diabetes and hypertension |
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| Authors | |
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Vnitřní lékařství |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | nephropathy; contrast media induced nephropathy; risk factors; preventive measures; ACE inhibitors; furosemide |
| Description | Contrastmedia-induced nephropathy (CMIN) is accompanied by high morbidity, lengthy hospitalisation and a higher mortality rate. In proportion to the rising number of diagnostic and interventional radiological procedures, the prevalence of this complication is also rising. The study briefly tackles the currently known pathophysiological mechanisms that lead to CMIN and deals with various risk factors witch increase the probability of development of contrast nephropathy. Among these factors are, in first place, diabetes mellitus, a púre-existing renal illness and hyperetension. In addition, the risk ofdeveloping CMIN sugnificantely increases in patients on risky medication. In our study, this medication was a combination of ACE inhibitors and furosemide. Enen though none of the patients met the criteria defined for CMIN, radiocontrast examination showed a significant statistical decline in GFR and a rise in proteinuria in the sub group which used zhis combined medication.The risk level of this medication especially in patients with pre-existing nephropathy is also underlined by the suggested dependency of the relative rise in the serum levels of creatinine in terms of its input value. It is necessary, as early as the radiocontrast examination is being done, to bare in mind the possibility of CMIN occurring and avoid it also through the modification of the risk factors which can be influenced, e.g. elimination of risky medication and in indicated cases, taking preventove measures. |
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