New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways

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Authors

KOUTNÁ Irena KRONTORÁD Petr SVOBODA Zbyněk BÁRTOVÁ Eva KOZUBEK Michal KOZUBEK Stanislav

Year of publication 2007
Type Article in Periodical
Magazine / Source Genomics
MU Faculty or unit

Faculty of Informatics

Citation
Field Genetics and molecular biology
Keywords Gene clustering; Differentiation; Microarrays; HL-60; K-562
Description To understand how genes are distributed on chromosomes we bring new insights into gene positional clustering and its properties. We have made a large-scale analysis of three types of differentiation and we observed that genes that subsequently enter into different cell processes are positionally clustered on chromosomes. Genes from the clusters are transcribed subsequently with respect to time kinetics and also to position. This means that the genes related to a cellular process are clustered together, independent of the period of time during which they are active and important for the process. Our results also demonstrate not only that there are general regions of increased or decreased levels of gene expression, but also that, in fact, in some chromosome regions we can find clustering of genes related to specific cell processes. The results provided in this paper also support the theory of transcription factories and show that transcription of genes from the clusters is managed by softer epigenetic mechanisms.
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