A comparison of the trough-peak ratio of cardio-selective beta-blockers in patients with newly diagnosed hypertension.
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Blood pressure monitoring |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | blood pressure monitoring;hypertension;trough-to-peak ratio;beta-blockers. |
| Description | The drug can be administered once a day, if the tough-to-peak ratio (T/P) exceeds 50-66%. The mean T/P of betaxolol hydrochloride was calculated 72,84 +- 33,32% (95% CI, 60,40-85,28%) for systolic BP and 71,57 +-29,35% (95% CI, 60,62-82,53%) for diastolic BP. The mean T/P of metoprolol tartrate was calculated 70,59 +- 31,66% (95% CI, 58,76-82,41%) fo systolic BP and 66,95 +- 31,60% (95% CI, 55,15-78,75%) for diastolic BP. 95% CI - 95% confidence interval. Conclusion: The T/P ratio determined for betaxolol hydrochloride and metoprolol tartrate is higher than 66%. The ratio garatees a satisfactory 24-h effect of both the above mentioned drugs. |
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