Dvacetčtyřhodinová účinnost metoprolol tartrátu u pacientů s čerstvě zjištěnou hypertenzí
| Title in English | Twenty four hour effectiveness of metoprolol tartrate in patients with newly diagnosed hypertension. |
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| Authors | |
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Praktický lékař |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | hypertension;beta-blockers;metoprolol tartrat;smoothness index. |
| Description | Objective: To determine the 24hour effectiveness of metorpolol tartrate used once daily using smoothness index (SI). Design and Methods: BP measurement using 24-hour ambulatory blood pressure monitoring (SpaceLabs 90207) according to the ESH criteria. We evaluated 30 patients before and after the 3months of treatment with mean dose 150mg slow-release metoprolole. The smoothness index was obtained by calculating the average BP values for each hour of the 24-hour monitoring period, both before and during treatment. From these, all hourly changes in BP induced by treatment were obtained, and the average of these hourly values was divided by its standard deviation. Results: SI of metoprolol tartrate for systolic BP was 1,26 +- 0,87 (95% CI, 0,95-1,57) and diastolic BP was 1,46 +- 1,13 (95% CI, 1,06-1,86). 95% CI - 95% confidence interval, SD - standard deviation. Conclusion: SI metoprolol tartrate is higher than 1,0 for both systolic and diastolic blood pressure values. According to the value of SI metoprolol tartrate has sufficient 24hour effectiveness and may by used once daily. |
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